Impact of pramipexole on the onset of levodopa‐related dyskinesias
Identifieur interne : 002E06 ( Main/Exploration ); précédent : 002E05; suivant : 002E07Impact of pramipexole on the onset of levodopa‐related dyskinesias
Auteurs : Radu Constantinescu [États-Unis] ; Megan Romer [États-Unis] ; Michael P. Mcdermott [États-Unis] ; Cornelia Kamp [États-Unis] ; Karl Kieburtz [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-07-15.
English descriptors
- KwdEn :
- Aged, Akathisia, Drug-Induced (etiology), Antiparkinson Agents (adverse effects), Benzothiazoles (adverse effects), Double-Blind Method, Female, Humans, Levodopa (adverse effects), Male, Middle Aged, Parkinson Disease (drug therapy), Parkinson's disease, Probability, dopamine agonists, dyskinesias, levodopa, pramipexole.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Benzothiazoles, Levodopa.
- drug therapy : Parkinson Disease.
- etiology : Akathisia, Drug-Induced.
- Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Probability.
Abstract
Dyskinesias are a major complication of dopaminergic therapy in the long‐term treatment of Parkinson's disease. In the CALM‐PD trial, subjects were initially randomized to levodopa or pramipexole and could later add levodopa if needed. After adjusting for disease duration and daily levodopa dosage, the incidence of dyskinesias after initiating levodopa was not significantly different among subjects initially randomized to levodopa and those initially randomized to pramipexole. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21292
Affiliations:
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Mcdermott</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Rochester Medical Center, Rochester, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kamp, Cornelia" sort="Kamp, Cornelia" uniqKey="Kamp C" first="Cornelia" last="Kamp">Cornelia Kamp</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Rochester Medical Center, Rochester, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Rochester Medical Center, Rochester, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-07-15">2007-07-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1317">1317</biblScope><biblScope unit="page" to="1319">1319</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B0896B7AACAB7F89FDC7897DCC5BD214C3C4D1C5</idno><idno type="DOI">10.1002/mds.21292</idno><idno type="ArticleID">MDS21292</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Akathisia, Drug-Induced (etiology)</term><term>Antiparkinson Agents (adverse effects)</term><term>Benzothiazoles (adverse effects)</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson's disease</term><term>Probability</term><term>dopamine agonists</term><term>dyskinesias</term><term>levodopa</term><term>pramipexole</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Benzothiazoles</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Akathisia, Drug-Induced</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Probability</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dyskinesias are a major complication of dopaminergic therapy in the long‐term treatment of Parkinson's disease. In the CALM‐PD trial, subjects were initially randomized to levodopa or pramipexole and could later add levodopa if needed. After adjusting for disease duration and daily levodopa dosage, the incidence of dyskinesias after initiating levodopa was not significantly different among subjects initially randomized to levodopa and those initially randomized to pramipexole. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Constantinescu, Radu" sort="Constantinescu, Radu" uniqKey="Constantinescu R" first="Radu" last="Constantinescu">Radu Constantinescu</name></region><name sortKey="Kamp, Cornelia" sort="Kamp, Cornelia" uniqKey="Kamp C" first="Cornelia" last="Kamp">Cornelia Kamp</name><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name><name sortKey="Mcdermott, Michael P" sort="Mcdermott, Michael P" uniqKey="Mcdermott M" first="Michael P." last="Mcdermott">Michael P. Mcdermott</name><name sortKey="Mcdermott, Michael P" sort="Mcdermott, Michael P" uniqKey="Mcdermott M" first="Michael P." last="Mcdermott">Michael P. Mcdermott</name><name sortKey="Romer, Megan" sort="Romer, Megan" uniqKey="Romer M" first="Megan" last="Romer">Megan Romer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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